Endocrine Abstracts

Somatostatin analogues (SSA) are first/second line treatment in the management of acromegaly and Cushing disease (CD), however, recent data suggest that they can be effective in the management of non-functioning pituitary neuroendocrine tumour (PitNET). We present one clinically silent gonadotroph PitNET treated with octreotide and two silent corticotroph PitNETs treated with pasireotide.Case 1: A 50-year-old female presented with frontal headache and vi...

Traumatic thoracic injuries in children and adolescents are rare, but could be connected with others traumas, often with traumatic brain injury (TBI). Based on data in the current literature, approximately 15–20% of TBI patients develop chronic hypopituitarism. Growth hormone (GH) and ACTH deficiency are the most common, followed by gonadotropins and thyroid-stimulating hormone. The greatest challenge associated with endocrine complications in individuals with polytrauma ...

Cushing syndrome due to ectopic (adrenocorticotropic hormone) ACTH secretion (EAS) constitutes approximately 10% of Cushing’s syndrome (CS). In this group only in about 5% cases pheochromocytoma is the source of ACTH.We present two patients with EAS by pheochromocytoma.1. A 70 year-old woman with 3-months history of malaise, weakness, abdominal pain, loss of weight and appetite, hypertension and diabetes mellitus. One month ea...

Objective: The management of pituitary tumors causing Cushing’s Disease are a multidisciplinary challenge to clinicians with neurosurgery as a first line treatment followed by the radiotherapy and pharmacotherapy including chemiotherapy.Such tumors are difficult to treat with high rate of recurrence. To date only 25 patients with Cushing Disease treated with the new alkylating agent temozolamide (TMZ) have been reported.Materials and methods: Sixty-...

Thyroid function in pregnancy differs between populations. The aim of the study was to assess thyroid parameters in Polish pregnant women. It included 1095 pregnant volunteers aged 16–42 years (174, 501, 420 in the 1st, 2nd, and 3rd trimester, respectively), who gave their informed written consent. In each woman thyroid ultrasound was performed, 90.7% had TSH, fT4 and a-TPO measured, and 84.0% iodine urinary concentration (UIC) in urine spot sample estimated.<p class=...

Introduction: Type 1 iodothyronine deiodinase (DIO1) is one of the three enzymes regulating bioavailability of thyroid hormones. In contrast to DIO2 and DIO3, the specific cellular role of DIO1 remains controversial. Our previous studies showed that DIO1 expression in clear cell renal cell carcinoma (ccRCC) is decreased, followed by lowered intracellular T3 concentration. In this study we explored how re-introduction of DIO1 in ccRCC cells affects their mig...

GEPNETs are rare tumors of very variable biology, particularly proliferative potential. Improved knowledge of the clinical course of disease may lead to proper identification of patients requiring more aggressive approach.Aim: i) characteristics of GEP-NET patients of the Endocrinology Department, University Hospital in Krakow, Poland; ii) identification of factors influencing their 5-year survival.Material and methods: Study inclu...

Cancer registers are important tools in improving the knowledge of epidemiology of rare malignancies, such as gastro-entero-pancreatic neuroendocrine tumors.Aim: To assess the epidemiology of GEPNETs in Krakow and Krakow district area between January 2007 and December 2011.Material and methods: To assess the epidemiology of GEPNETs in Krakow area a register was created, based on independent sources of information. 88 patients (49 f...

Abstract Identification of factors influencing survival of the gastro-entero-pancreatic neuroendocrine tumors patients may improve their management by better selection of subjects requiring more closed follow-up and more aggressive therapeutic approach.Aim: To assess factors influencing survival of GEPNET patients livingin Krakow and Krakow district area.Material and methods: The data from GEPNETs register run in t...

Introduction: The aim of this study was to assess the survival rate of patients with disseminated or inoperable neuroendocrine tumors (NETs) after PRRT with the use of 90Y-DOTATATE combined with long acting somatostatin analogue.Materials and methods: 72 patients were treated with PRRT in our Department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up to a total of 7.4 GBq/m2 administra...